Receptor-mediated actions of renin and prorenin
نویسندگان
چکیده
منابع مشابه
Renin, prorenin and the putative (pro)renin receptor.
Renin is an aspartic protease that consists of 2 homologous lobes. The cleft in between contains the active site with 2 catalytic aspartic residues.1 Unlike other aspartic proteases such as pepsin or cathepsin D, renin is monospecific and only cleaves angiotensinogen, to generate angiotensin (Ang) I. Ang I is the precursor of the active end-product of the renin-angiotensin system (RAS), Ang II....
متن کاملCritical review of prorenin and (pro)renin receptor research.
The renin-angiotensin system (RAS) plays an important role in cardiovascular and renal physiology and disease, and the benefits of angiotensin-converting enzyme inhibitor, angiotensin type 1 receptor blocker, and renin inhibitor therapies are mediated in part by their modification of the levels and actions of angiotensin peptides. Despite its long history, the RAS remains an active area of rese...
متن کامل(Pro)renin receptor and prorenin: their plausible sites of interaction.
Before discovery of (pro)renin receptor, prorenin was regarded as a source of renin and probable diagnostic marker for diabetic nephropathy/Wilms' tumor. It is now considered that prorenin can perform renin activity by binding to (P)RR and binding mechanism of (pro)renin to (P)RR was indicated in many in vitro studies. Considering the physiological importance and pathological involvement of (P)...
متن کاملProrenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor.
OBJECTIVE Mannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such binding contributes to renin/prorenin clearance but not to angiotensin generation. Here, we evaluated the kinetics of renin/prorenin binding to the recently discovered human (pro)renin receptor (h(P)RR), and the idea that such binding underlies tissue angiotensin generation. METHODS AND RESULTS Vascular smoo...
متن کاملPurification of renin and prorenin.
In this issue of the journal, we feature two articles—one by Tadashi Inagami and the other by Pierre Corvol and Joel Menard—relating the story of the purification of renin. These investigators received the 1985 CIBA Award for Hypertension Research for biochemical studies leading to the isolation, amino acid structural and three-dimensional configuration, and the physiochemical and immunochemica...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2006
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5000079